The medium-to-large sized mammals (Artiodactyla, Primate, and Carnivora) at the eastern part of Yushan Naitonal Park was monitored by signs tracking and automatic cameras on a monthly basis from April to December, 2008. Paired cameras designed to compare human and wildlife activity simultaneusly on four sites on the trail were set. A questionair survey was performed to collect travel information and wildlife sightings of visitors. The results show that the relative abundance and distribution of each species in Walami and Pao-ai were different, which can partly be attributed to the difference in tourist disturbance of the two areas. Among the species, muntjac and monkey were more easily found in Walami area, others showed higher activity records in Pao-ai area. When themonitoring data of the study area collected since 2003 were examined, some species were less common or abundanct this year than the years before, such as wild boar in Walami area. However, the observations on sambar and seorw increased in Walami area. The records from the paired cameras showed tourist pressure is decreasing from Nan-on to Pao-ai, while records on trail were more than records off trail. Questionair survey showed only about 20% of tourists hike beyond Walami, and 80% have observed or heard monkeys or muntjacs on trail. Some reported to have seen pet dogs in the area. The spatial variation and temporal trend of the relative abundance of wildlife species between Walamiand Pao-ai areas and during the past six years may be animals’ responses to tourist disturbance in the area.